No. 8: Modesto, Calif.
George Lucas of Star Wars fame was born in Modesto, and one of his first movies, American Graffiti, was about teenagers cruising the streets of Modesto at night. Modesto could use some of Lucas' $3.9 billion fortune, as unemployment was an unseemly 8.7% in 2007. Of course, that is down from the early 1990s, when it topped 15%.
Sources: Bert Sperling; Moody's Economy.com; U.S. Census Bureau